Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 12/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4838056 | 0.86 | CA1 (0.45) | NR1H2KDM4EKMT2A | |
| SCHEMBL4794680 | 0.81 | NR1H2 (0.46) | NR1H2MAPK1HTTHDAC8 | |
| SCHEMBL4844918 | 0.81 | NR1H2 (0.39) | NR1H2KMT2ANR1H3 | |
| SCHEMBL4785715 | 0.79 | TBXA2R (0.40) | NR1H2 | |
| SCHEMBL4902040 | 0.79 | NR1H2 (0.38) | NR1H2KMT2ANR1H3 | |
| SCHEMBL4784555 | 0.79 | CA1 (0.51) | KDM4EKMT2AHDAC8 | |
| SCHEMBL4844757 | 0.79 | TBXA2R (0.41) | NR1H2NR1H3 | |
| SCHEMBL4900753 | 0.79 | KDM4E (0.43) | NR1H2KDM4EKMT2ANR1H3HTT | |
| SCHEMBL4911955 | 0.79 | KDM4E (0.43) | NR1H2KDM4EKMT2ANR1H3HTT | |
| SCHEMBL4782504 | 0.77 | NR1H2 (0.55) | NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |