Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | HEXA | P06865 | 1/20 | 0.41 |
| ▸ | HEXB | P07686 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4113326 | 0.96 | MAP4K4 (0.56) | MAP4K4DHFRADORA2AALDH1A1HPGD | |
| SCHEMBL4107851 | 0.91 | HRH2 (0.51) | HRH2HRH3DHFRADORA2AALDH1A1 | |
| SCHEMBL4114967 | 0.83 | NPC1 (0.43) | MAP4K4HRH2HRH3DHFRADORA2A | |
| SCHEMBL4114833 | 0.81 | MAOB (0.46) | MAP4K4DHFR | |
| SCHEMBL4101904 | 0.81 | CYP1A2 (0.48) | MAP4K4DHFRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4114040 | 0.81 | MAP4K4 (0.54) | MAP4K4DHFRADORA2AALDH1A1LMNA | |
| SCHEMBL4106840 | 0.80 | ALDH1A1 (0.43) | MAP4K4HRH2HRH3DHFRALDH1A1 | |
| SCHEMBL4096146 | 0.79 | MAP4K4 (0.41) | MAP4K4HRH2HRH3DHFRMAPT | |
| SCHEMBL4095683 | 0.79 | DHFR (0.51) | MAP4K4DHFRMAPTTLR8TLR7 | |
| SCHEMBL4107041 | 0.78 | GAA (0.42) | ADORA2AALDH1A1LMNAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009076-A2 | SUBSTITUTED PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | claimed |