Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12834084 | 0.75 | ERN1 (0.57) | ERN1ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL1922020 | 0.75 | ERN1 (0.55) | ERN1ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL5896326 | 0.73 | ALDH1A1 (0.46) | ERN1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL27317315 | 0.73 | HSD11B1 (0.45) | ERN1ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL10921345 | 0.73 | HSD11B1 (0.42) | ERN1ALDH1A1NPC1LMNAMAPT | |
| SCHEMBL31183331 | 0.73 | ERN1 (0.48) | ERN1ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL692164 | 0.73 | ERN1 (0.48) | ERN1ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL31183326 | 0.73 | ERN1 (0.48) | ERN1ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL4967830 | 0.73 | ERN1 (0.39) | ERN1ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL6535907 | 0.73 | ERN1 (0.61) | ERN1ALDH1A1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354954-B1 | Use of GABA agonists for treatment of spastic disorders, convulsions, and epilepsy | UAB RESEARCH FOUNDATION, THE | 2008-04-08 | — | — | US | claimed |
| US-7354954-B1 | Use of GABA agonists for treatment of spastic disorders, convulsions, and epilepsy | UAB RESEARCH FOUNDATION, THE | 2008-04-08 | — | — | US | disclosed |
| US-20060142396-A1 | Use of GABA agonists for the treatment of spastic disorders, convulsions, epilepsy, and neuroprotection | THE UAB RESEARCH FOUNDATION (US) | 2006-06-29 | — | — | US | disclosed |
| EP-1202720-A4 | USE OF GABA AGONISTS FOR TREATMENT OF SPASTIC DISORDERS, CONVULSIONS, AND EPILEPSY | UAB RESEARCH FOUNDATION (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1202720-A1 | USE OF GABA AGONISTS FOR TREATMENT OF SPASTIC DISORDERS, CONVULSIONS, AND EPILEPSY | UAB Research Foundation (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001010432-A1 | USE OF GABA AGONISTS FOR TREATMENT OF SPASTIC DISORDERS, CONVULSIONS, AND EPILEPSY | UAB RESEARCH FOUNDATION (US) | 2001-02-15 | — | — | WO | disclosed |