Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4845329 | 1.00 | NFE2L2 (0.56) | NFE2L2KDM4EHPGDLMNATRPM8 | |
| SCHEMBL8357109 | 0.87 | ABCG2 (0.47) | NFE2L2KDM4EHPGDLMNATP53 | |
| SCHEMBL13018860 | 0.82 | MAPT (0.40) | NFE2L2KDM4EHPGDLMNAALDH1A1 | |
| SCHEMBL14462725 | 0.81 | NFE2L2 (0.59) | NFE2L2KDM4EHPGDLMNATRPM8 | |
| SCHEMBL10395173 | 0.77 | KMT2A (0.45) | KDM4EHPGDLMNATP53CYP1A1 | |
| SCHEMBL24037066 | 0.77 | RECQL (0.40) | LMNAADORA2AADORA2BADORA1CYP1A2 | |
| SCHEMBL10666690 | 0.77 | NFE2L2 (0.55) | NFE2L2KDM4EHPGDLMNATRPM8 | |
| SCHEMBL7789732 | 0.77 | BACE1 (0.46) | HPGDLMNA | |
| SCHEMBL17318680 | 0.77 | RECQL (0.45) | NFE2L2LMNAALDH1A1 | |
| SCHEMBL17318679 | 0.77 | RECQL (0.45) | NFE2L2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963918-A1 | PHOTOCHROMIC 2H-NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2008-09-03 | — | — | EP | disclosed |
| US-20070145337-A1 | Photochromic 2H-naphthopyrans | TRANSITIONS OPTICAL, INC. | 2007-06-28 | — | — | US | disclosed |
| WO-2007073463-A1 | PHOTOCHROMIC 2H-NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2007-06-28 | — | — | WO | disclosed |
| US-4975463-A | VIRICIDES; AIDS TREATMENT | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 1990-12-04 | — | — | US | disclosed |