Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.76 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.76 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.76 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | USP2 | O75604 | 1/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.76 |
| ▸ | THRB | P10828 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | TP53 | P04637 | 1/20 | 0.76 |
| ▸ | GLA | P06280 | 1/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.76 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.76 |
| ▸ | DRD4 | P21917 | 1/20 | 0.76 |
| ▸ | HTR1B | P28222 | 1/20 | 0.76 |
| ▸ | HTR2C | P28335 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6056296 | 0.86 | HTR1A (0.71) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL29908300 | 0.86 | HTR1A (1.00) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL29379249 | 0.86 | HTR1A (1.00) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL1157882 | 0.86 | HTR1A (1.00) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL1157556 | 0.86 | HTR1A (1.00) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL5219 | 0.86 | HTR1A (1.00) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL5220 | 0.86 | HTR1A (1.00) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| SCHEMBL9450011 | 0.86 | ADRB3 (0.57) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL561162 | 0.85 | HTR1A (0.97) | HTR1AADRB2ADRB1ADRB3CYP1A2 | |
| Pindolol SCHEMBL2991558 | 0.85 | HTR1A (0.97) | HTR1AADRB2ADRB1ADRB3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449480-B2 | Small molecule inhibitors of HER2 expression | BAYLOR COLLEGE OF MEDICINE (US) | 2008-11-11 | — | — | US | disclosed |
| US-7019017-B2 | Small molecule inhibitors of HER2 expression | BAYLOR COLLEGE OF MEDICINE (US) | 2006-03-28 | — | — | US | disclosed |
| US-20050288327-A1 | Small molecule inhibitors of HER2 expression | UESUGI MOTONARI | 2005-12-29 | — | — | US | disclosed |
| US-20050283007-A1 | Small molecule inhibitors of HER2 expression | BAYLOR COLLEGE OF MEDICINE | 2005-12-22 | — | — | US | disclosed |
| WO-2005074933-A1 | SMALL MOLECULE INHIBITORS OF HER2 EXPRESSION | BAYLOR COLLEGE OF MEDICINE (US) | 2005-08-18 | — | — | WO | disclosed |
| US-20040006106-A1 | Small molecule inhibitors of HER2 expression | BAYLOR COLLEGE OF MEDICINE | 2004-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050283007-A1 | Small molecule inhibitors of HER2 expression | ERBB2, ABCC2, SLC2A2 | HTR1A 675/4885ADRB2 682/4885ADRB1 1603/4885 |
| US-20050288327-A1 | Small molecule inhibitors of HER2 expression | ERBB2, ABCC2, SLC2A2 | HTR1A 675/4885ADRB2 682/4885ADRB1 1603/4885 |
| US-20040006106-A1 | Small molecule inhibitors of HER2 expression | ERBB2, EGFR, ABCC2 | HTR1A 607/4885ADRB2 654/4885ADRB1 1400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.