Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3946457 | 0.98 | ALDH1A1 (0.42) | ALDH1A1POLBHPGDSMN1; SMN2GAA | |
| SCHEMBL23854195 | 0.96 | POLB (0.39) | ALDH1A1POLBHPGDSMN1; SMN2GAA | |
| SCHEMBL17560355 | 0.82 | CHRNB2 (0.42) | POLBHPGDHSD11B1 | |
| SCHEMBL18399277 | 0.82 | TSHR (0.52) | ALDH1A1POLBSMN1; SMN2HTTTSHR | |
| SCHEMBL28943426 | 0.79 | SMN1; SMN2 (0.40) | ALDH1A1POLBHPGDSMN1; SMN2GAA | |
| SCHEMBL21066382 | 0.78 | ALDH1A1 (0.39) | ALDH1A1POLBHPGDSMN1; SMN2GAA | |
| SCHEMBL4725324 | 0.77 | ALDH1A1 (0.42) | ALDH1A1POLBHPGDSMN1; SMN2GAA | |
| SCHEMBL3885999 | 0.76 | EPHX1 (0.44) | ALDH1A1POLBHPGDHTTCHRM1 | |
| SCHEMBL30443406 | 0.76 | ALDH1A1 (0.54) | ALDH1A1POLBHPGDSMN1; SMN2GAA | |
| SCHEMBL28195034 | 0.75 | ALDH1A1 (0.43) | ALDH1A1POLBHPGDSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4346898-A1 | METHODS FOR INHIBITING RAS | Revolution Medicines, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| WO-2023208005-A1 | CYCLIC COMPOUNDS, PREPARATION METHODS AND MEDICINAL USES THEREOF | HANSOH BIO LLC (US) | 2023-11-02 | — | — | WO | disclosed |
| WO-2022251292-A1 | METHODS FOR INHIBITING RAS | Revolution Medicines, Inc. (US) | 2022-12-01 | — | — | WO | disclosed |
| EP-3071564-A1 | DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS | Sunshine Lake Pharma Co., Ltd. (CN) | 2016-09-28 | — | — | EP | disclosed |
| CN-103502240-B | Azole derivatives | 大正制药株式会社 | 2016-08-31 | — | — | CN | disclosed |
| CN-103068830-B | Arginase inhibitors and therapeutic uses thereof | 马尔斯公司 | 2016-06-29 | — | — | CN | disclosed |
| WO-2015074546-A1 | DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-05-28 | — | — | WO | disclosed |
| WO-2008011130-A2 | AMIDE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-24 | — | — | WO | disclosed |