Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4845805 | 0.82 | NPC1 (0.45) | NPC1 | |
| SCHEMBL5260640 | 0.78 | CHEK2 (0.34) | HDAC6CHEK2 | |
| SCHEMBL5259366 | 0.78 | NPC1 (0.49) | NPC1 | |
| SCHEMBL4834997 | 0.74 | HDAC6 (0.36) | HDAC6CHEK2 | |
| SCHEMBL4838292 | 0.74 | HDAC3 (0.34) | HDAC6CHEK2 | |
| SCHEMBL4843544 | 0.73 | CHEK2 (0.34) | NPC1HDAC6CHEK2 | |
| Trifluoroacetic Acid SCHEMBL5258414 | 0.70 | MEN1 (0.43) | — | |
| Trifluoroacetic Acid SCHEMBL4839654 | 0.70 | HDAC3 (0.48) | HDAC6CHEK2 | |
| Trifluoroacetic Acid SCHEMBL4844245 | 0.70 | MEN1 (0.47) | NPC1 | |
| SCHEMBL4840576 | 0.70 | HDAC6 (0.35) | HDAC6CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410966-B2 | Use of and some novel imidazopyridines | ASTRAZENECA AB (SE) | 2008-08-12 | — | — | US | disclosed |
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | disclosed |
| US-20050261333-A1 | Use of and some novel imidazopyridines | ASTRAZENECA A B (SE) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261333-A1 | Use of and some novel imidazopyridines | ITK, CSNK1A1, RPS6KA1 | NPC1 2655/4885HDAC6 981/4885CHEK2 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.