Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 11/20 | 0.62 |
| ▸ | EGFR | P00533 | 10/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.62 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.52 |
| ▸ | TUBB | P07437 | 3/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.52 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.52 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.52 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.52 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.52 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.52 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.52 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3124173 | 0.77 | KDR (1.00) | KDRPDGFRBEGFRPDGFRA | |
| SCHEMBL3110883 | 0.75 | KDR (0.54) | KDRPDGFRBEGFRPDGFRATUBB3 | |
| SCHEMBL14207894 | 0.74 | KDR (0.57) | KDRPDGFRBEGFRPDGFRATUBB3 | |
| SCHEMBL23077791 | 0.73 | KDR (0.66) | KDRPDGFRBEGFRPDGFRATUBB3 | |
| SCHEMBL13464866 | 0.73 | KDR (0.62) | KDRPDGFRBEGFRPDGFRATUBB3 | |
| SCHEMBL17528563 | 0.72 | KDR (0.58) | KDRPDGFRBEGFRPDGFRATUBB3 | |
| SCHEMBL18540821 | 0.72 | KDR (0.58) | KDRPDGFRBEGFRPDGFRATUBB3 | |
| SCHEMBL17528560 | 0.72 | KDR (0.58) | KDRPDGFRBEGFRPDGFRATUBB3 | |
| SCHEMBL1366266 | 0.72 | TUBB3 (0.61) | KDRPDGFRBEGFRPDGFRATUBB3 | |
| SCHEMBL3118973 | 0.71 | KDR (0.60) | KDRPDGFRBEGFRPDGFRATUBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057402-A2 | N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2008-05-15 | — | — | WO | claimed |
| WO-2008057402-A2 | N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2008-05-15 | — | — | WO | disclosed |