Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 8/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852855 | 1.00 | SLC6A9 (0.42) | SLC6A9HRH1KEAP1NFE2L2PDCD1 | |
| SCHEMBL4854720 | 0.94 | SLC6A9 (0.44) | SLC6A9HRH1KEAP1NFE2L2PDCD1 | |
| SCHEMBL4846166 | 0.94 | SLC6A9 (0.44) | SLC6A9HRH1KEAP1NFE2L2PDCD1 | |
| SCHEMBL4846416 | 0.91 | SLC6A9 (0.39) | SLC6A9HRH1KEAP1NFE2L2PDCD1 | |
| SCHEMBL4847435 | 0.87 | SLC6A9 (0.46) | SLC6A9HRH1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4853568 | 0.87 | SLC6A9 (0.46) | SLC6A9HRH1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4852459 | 0.87 | BACE1 (0.49) | SLC6A9HRH1KEAP1NFE2L2BACE1 | |
| SCHEMBL4855930 | 0.87 | BACE1 (0.49) | SLC6A9HRH1KEAP1NFE2L2BACE1 | |
| SCHEMBL4855924 | 0.85 | BACE1 (0.51) | KEAP1NFE2L2BACE1KDM4EALDH1A1 | |
| SCHEMBL4854144 | 0.85 | BACE1 (0.51) | KEAP1NFE2L2BACE1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |