Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854720 | 1.00 | SLC6A9 (0.44) | SLC6A9HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4846414 | 0.94 | SLC6A9 (0.42) | SLC6A9KEAP1NFE2L2PDCD1CD274 | |
| SCHEMBL4852855 | 0.94 | SLC6A9 (0.42) | SLC6A9KEAP1NFE2L2PDCD1CD274 | |
| SCHEMBL4854510 | 0.91 | KEAP1 (0.44) | SLC6A9HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6142473 | 0.91 | KEAP1 (0.44) | SLC6A9HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4846175 | 0.91 | HDAC3 (0.47) | SLC6A9HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4847435 | 0.86 | SLC6A9 (0.46) | SLC6A9HRH1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4853568 | 0.86 | SLC6A9 (0.46) | SLC6A9HRH1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4854689 | 0.85 | SLC6A9 (0.46) | SLC6A9HRH1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4855044 | 0.85 | SLC6A9 (0.46) | SLC6A9HRH1ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |