Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | TLR4 | O00206 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8502739 | 0.98 | ALDH1A1 (0.54) | ALDH1A1ALOX12MEN1KMT2AMAPT | |
| SCHEMBL6545133 | 0.84 | ALDH1A1 (0.42) | ALDH1A1ALOX12KMT2AKDM4EHPGD | |
| SCHEMBL6545071 | 0.81 | ALDH1A1 (0.51) | ALDH1A1ALOX12KMT2AMAPTHSD17B10 | |
| SCHEMBL28420809 | 0.81 | ALDH1A1 (0.56) | ALDH1A1ALOX12MEN1KMT2AMAPT | |
| SCHEMBL8953203 | 0.79 | MAPK1 (0.53) | ALDH1A1ALOX12GAA | |
| SCHEMBL9815379 | 0.79 | ALDH1A1 (0.47) | ALDH1A1ALOX12MEN1KMT2AMAPT | |
| SCHEMBL7127925 | 0.77 | ALDH1A1 (0.50) | ALDH1A1ALOX12MEN1KMT2AMAPT | |
| SCHEMBL1782540 | 0.77 | ALDH1A1 (0.40) | ALDH1A1ALOX12MEN1KMT2AMAPT | |
| SCHEMBL1262342 | 0.76 | ALDH1A1 (0.41) | ALDH1A1ALOX12MEN1KMT2AMAPT | |
| SCHEMBL680912 | 0.76 | ALDH1A1 (0.41) | ALDH1A1ALOX12MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1484325-B1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | JAPAN SCIENCE & TECH AGENCY (JP) | 2014-06-18 | — | — | EP | disclosed |
| US-20100204321-A1 | Antitussive and Bronchodilator uses for enaminone ester | KUWAIT UNIVERSITY (KW) | 2010-08-12 | — | — | US | disclosed |
| US-7453001-B2 | Such as, ethyl 3-(2-hydroxyphenyl)-6-methyl4-oxo4,5,6,7-tetrahydrobenzo[d]isoxazole-5-carboxylate; intermediates | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-11-18 | — | — | US | disclosed |
| US-7342036-B2 | Isoxazole derivatives and process for producing the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-03-11 | — | — | US | disclosed |
| US-20080058530-A1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-03-06 | — | — | US | disclosed |
| US-20050026978-A1 | Isoxazole derivatives and process for producing the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2005-02-03 | — | — | US | disclosed |
| EP-1484325-A1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Japan Science and Technology Agency (JP) | 2004-12-08 | — | — | EP | disclosed |
| EP-1027055-B1 | 3-CARBOALKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4(10H)-ONE DERIVATIVES | UNIV HOWARD (US) | 2004-01-07 | — | — | EP | disclosed |
| EP-1027055-A4 | 3-CARBOALKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4(10H)-ONE DERIVATIVES | UNIV HOWARD (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-1027055-A1 | 3-CARBOALKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4(10H)-ONE DERIVATIVES | HOWARD UNIVERSITY (US) | 2000-08-16 | — | — | EP | disclosed |
| US-5994349-A | ANTIEPILEPTIC AGENTS | HOWARD UNIVERSITY (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1999021560-A1 | 3-CARBOALKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4[10H]-ONE DERIVATIVES | HOWARD UNIVERSITY (US) | 1999-05-06 | — | — | WO | disclosed |
| US-5580894-A | NERVOUS SYSTEM DISORDERS | HOWARD UNIVERSITY (US) | 1996-12-03 | — | — | US | disclosed |
| US-4607120-A | A OMATIZATION | SOCIETE ANONYME ROURE BERTRAND DUPONT (FR) | 1986-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026978-A1 | Isoxazole derivatives and process for producing the same | CYP1A1, CYP1A2, CYP2E1 | ALDH1A1 67/4885ALOX12 382/4885MEN1 2139/4885 |
| US-20080058530-A1 | ISOXAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | CYP1A1, CYP1A2, CYP2E1 | ALDH1A1 67/4885ALOX12 382/4885MEN1 2139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.