Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 3/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.35 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL208846 | 0.87 | SIRT2 (0.38) | NR1H4HDAC1CA1CA2NAMPT | |
| SCHEMBL206551 | 0.85 | GLS (0.44) | GLSNR1H4HDAC1CA1CA2 | |
| SCHEMBL8384189 | 0.85 | GLS (0.42) | GLSNR1H4HDAC1CA1CA2 | |
| SCHEMBL17902840 | 0.85 | GLS (0.42) | GLSNR1H4HDAC1CA1CA2 | |
| SCHEMBL16089568 | 0.82 | GLS (0.42) | GLSNR1H4HDAC1CA1CA2 | |
| SCHEMBL18805056 | 0.82 | GLS (0.42) | GLSNR1H4HDAC1CA1CA2 | |
| SCHEMBL16099783 | 0.82 | GLS (0.42) | GLSNR1H4HDAC1CA1CA2 | |
| SCHEMBL19639379 | 0.81 | GLS (0.41) | GLSNR1H4CA1CA2BRD4 | |
| SCHEMBL15125610 | 0.81 | CTSB (0.47) | GLSNR1H4CA1CA2BRD4 | |
| SCHEMBL19651943 | 0.81 | CA1 (0.51) | HDAC1CA1CA2NAMPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378432-B2 | Glycogen synthase kinase-3 inhibitors | TEL AVIV UNIVERSITY FUTURE TECHNOLOGY DEVELOPMENT L.P. (IL) | 2008-05-27 | — | — | US | disclosed |