SCHEMBL4846664

SCHEMBL4846664

Nc1ccc(C(F)(F)F)cc1C(=O)NCC(=O)N[C@@H]1CCNC1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 20/20 0.66
CCR3 P51677 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4846680 1.00 CCR2 (0.66) CCR2CCR3
SCHEMBL4849796 0.85 CCR2 (0.61) CCR2CCR3
SCHEMBL4847640 0.85 CCR2 (0.61) CCR2CCR3
SCHEMBL4840816 0.82 CCR2 (0.66) CCR2CCR3
Acetic Acid SCHEMBL5702355 0.82 CCR2 (0.57) CCR2CCR3
Acetic Acid SCHEMBL5702362 0.82 CCR2 (0.57) CCR2CCR3
Nitric Acid SCHEMBL5268257 0.81 CCR2 (0.57) CCR2CCR3
Nitric Acid SCHEMBL5268270 0.81 CCR2 (0.57) CCR2CCR3
SCHEMBL744023 0.81 CCR2 (0.70) CCR2
SCHEMBL1360171 0.81 CCR2 (0.70) CCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100418951-C Cycloamine derivative and its use as medicine TEIJIN KASEI LTD (JP) 2008-09-17 CN disclosed
US-7390830-B1 Remedies or prophylactics for diseases in association with chemokines TEIJIN LIMITED (JP) 2008-06-24 US disclosed
CN-1240699-C Therapeutic or prophylactic agent for chemokine-associated diseases TEIJIN LTD (JP) 2006-02-08 CN disclosed
EP-1179341-B1 REMEDIES OR PREVENTIVES FOR DISEASES IN ASSOCIATION WITH CHEMOKINES TEIJIN LTD (JP) 2005-11-09 EP disclosed
CN-1660815-A Cyclic amine derivatives and their use as drugs TEIJIN LTD (JP) 2005-08-31 CN disclosed
EP-1553085-A1 Cyclic amine derivatives and their use as drugs TEIJIN LIMITED (JP) 2005-07-13 EP disclosed
EP-1535909-A2 Cyclic amine derivatives and their use as drugs TEIJIN LIMITED (JP) 2005-06-01 EP disclosed
CN-1496981-A Cyclic amine derivatives and their use as pharmaceuticals ������������ʽ���� 2004-05-19 CN disclosed
CN-1384743-A Remedies or preventives for diseases in association with chemokines TEIJIN LTD (JP) 2002-12-11 CN disclosed
US-6451842-B1 Cyclic amine derivatives and their use as drugs DUPONT PHARMACEUTICALS COMPANY 2002-09-17 US disclosed
US-6410566-B1 ATHEROSCLEROSIS; ANTIARTHRITIC AGENTS TEIJIN LIMITED (JP) 2002-06-25 US disclosed
US-6362177-B1 INHIBITION OF CHEMOKINE BINDING TEIJIN LIMITED (JP) 2002-03-26 US disclosed
EP-1179341-A1 REMEDIES OR PREVENTIVES FOR DISEASES IN ASSOCIATION WITH CHEMOKINES TEIJIN LIMITED (JP) 2002-02-13 EP disclosed
CN-1279668-A Cyclic amine derivatives and their use as pharmaceuticals TEIJIN LTD (JP) 2001-01-10 CN disclosed