Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | CCR9 | P51686 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306821 | 0.80 | CYP2C9 (0.53) | CCR2CYP3A4CYP2C9 | |
| SCHEMBL130229 | 0.77 | CCR2 (0.53) | CCR2CYP3A4TSHRALDH1A1LMNA | |
| SCHEMBL170277 | 0.76 | CCR2 (0.60) | CCR2CYP3A4CYP2C9TSHRALDH1A1 | |
| SCHEMBL15259955 | 0.75 | CCR2 (0.58) | CCR2CYP3A4CYP2C9TSHRALDH1A1 | |
| SCHEMBL5568798 | 0.73 | CCR2 (0.49) | CCR2CYP3A4TSHRALDH1A1LMNA | |
| SCHEMBL130228 | 0.71 | CCR2 (0.52) | CCR2CYP3A4TSHRALDH1A1LMNA | |
| SCHEMBL305651 | 0.71 | CYP2C9 (0.55) | CCR2CYP3A4CYP2C9TSHRALDH1A1 | |
| SCHEMBL1188125 | 0.71 | CYP2C9 (0.79) | CCR2CYP3A4CYP2C9TSHRALDH1A1 | |
| SCHEMBL1762417 | 0.70 | CCR2 (0.63) | CCR2CYP3A4CYP2C9TSHRALDH1A1 | |
| SCHEMBL12594276 | 0.70 | CCR2 (0.65) | CCR2CYP3A4CYP2C9TSHRPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008431-A2 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |