Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.52 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.52 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4847170 | 1.00 | MEN1 (0.52) | MEN1KMT2AMAPTKDM4ETNNI3 | |
| Hydrochloric Acid SCHEMBL7437004 | 0.99 | MEN1 (0.51) | MEN1KMT2AMAPTKDM4ETNNI3 | |
| Hydrochloric Acid SCHEMBL7437016 | 0.99 | MEN1 (0.51) | MEN1KMT2AMAPTKDM4ETNNI3 | |
| SCHEMBL29478385 | 0.89 | CA12 (0.54) | MEN1KMT2AMAPTKDM4ETNNI3 | |
| SCHEMBL42286 | 0.89 | CA12 (0.54) | MEN1KMT2AMAPTKDM4ETNNI3 | |
| SCHEMBL298855 | 0.89 | CA12 (0.54) | MEN1KMT2AMAPTKDM4ETNNI3 | |
| SCHEMBL29367675 | 0.89 | CA12 (0.54) | MEN1KMT2AMAPTKDM4ETNNI3 | |
| SCHEMBL42287 | 0.89 | CA12 (0.54) | MEN1KMT2AMAPTKDM4ETNNI3 | |
| SCHEMBL409050 | 0.89 | CA12 (0.54) | MEN1KMT2AMAPTKDM4ETNNI3 | |
| Ammonia Solution, Strong SCHEMBL466943 | 0.88 | CA12 (0.53) | MEN1KMT2AMAPTKDM4ETNNI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012112945-A1 | USE OF MATRIX METALLOPROTEINASE INHIBITORS TO TREAT TUBERCULOSIS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-08-23 | — | — | WO | claimed |
| US-9750789-B2 | Use of matrix metalloproteinase inhibitors to treat tuberculosis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-09-05 | — | — | US | disclosed |
| WO-2012112945-A1 | USE OF MATRIX METALLOPROTEINASE INHIBITORS TO TREAT TUBERCULOSIS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-08-23 | — | — | WO | disclosed |
| EP-1986657-A2 | METHOD OF TREATING A SUBJECT SUFFERING FROM DEGENERATIVE DISC DISEASE USING A MATRIX METALLOPROTEASE INHIBITOR | Discogen, LLC (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007098099-A2 | METHOD OF TREATING A SUBJECT SUFFERING FROM DEGENERATIVE DISC DISEASE USING A MATRIX METALLOPROTEASE INHIBITOR | DISCOGEN, LLC (US) | 2007-08-30 | — | — | WO | disclosed |