Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 7/20 | 0.69 |
| ▸ | HEXA | P06865 | 1/20 | 0.62 |
| ▸ | HEXB | P07686 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | GHSR | Q92847 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6347041 | 0.97 | DHFR (0.74) | DHFRHEXAHEXBCYP2D6GHSR | |
| SCHEMBL6342295 | 0.93 | DHFR (0.60) | DHFRHEXAHEXBCYP2D6GHSR | |
| SCHEMBL4838316 | 0.87 | DHFR (0.71) | DHFR | |
| SCHEMBL5086319 | 0.84 | DHFR (0.69) | DHFRHEXAHEXB | |
| SCHEMBL4838823 | 0.82 | DHFR (1.00) | DHFRHEXAHEXBGHSR | |
| SCHEMBL3502224 | 0.81 | DHFR (0.78) | DHFRHEXAHEXBCYP2D6 | |
| SCHEMBL3633466 | 0.80 | GHSR (0.88) | DHFRGHSR | |
| SCHEMBL6338781 | 0.80 | DHFR (0.63) | DHFRHEXAHEXBGHSR | |
| SCHEMBL6703985 | 0.79 | DHFR (0.67) | DHFRGHSR | |
| SCHEMBL3498787 | 0.77 | HEXA (1.00) | DHFRHEXAHEXBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371758-B2 | Antimalarial pyrimidine derivatives and methods of making and using them | NATIONAL SCIENCE & TECHNOLOGY DEVELOPMENT AGENCY (TH) | 2008-05-13 | — | — | US | claimed |
| US-7371758-B2 | Antimalarial pyrimidine derivatives and methods of making and using them | NATIONAL SCIENCE & TECHNOLOGY DEVELOPMENT AGENCY (TH) | 2008-05-13 | — | — | US | disclosed |
| US-20040180913-A1 | Antimalarial pyrimidine derivatives and methods of making and using them | NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY (TH) | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180913-A1 | Antimalarial pyrimidine derivatives and methods of making and using them | DHFR, TYMP, TYMS | DHFR 1/4885HEXA 1841/4885HEXB 1987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.