Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.52 |
| ▸ | BCHE | P06276 | 6/20 | 0.50 |
| ▸ | ACHE | P22303 | 4/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4857311 | 0.88 | BCHE (0.47) | BCHEACHEHRH1 | |
| SCHEMBL4853880 | 0.88 | BCHE (0.47) | BCHEACHEHRH1 | |
| SCHEMBL4853318 | 0.87 | MAOB (0.62) | MAOBBCHEACHEMAOA | |
| SCHEMBL5915415 | 0.86 | ABCG2 (0.61) | MAOBACHEMAOAABCG2 | |
| SCHEMBL25202533 | 0.86 | BCHE (0.65) | MAOBBCHEACHEHRH1MAOA | |
| SCHEMBL4856397 | 0.85 | SLC6A9 (0.47) | MAOBBCHEACHEHRH1 | |
| SCHEMBL4854959 | 0.85 | SLC6A9 (0.47) | MAOBBCHEACHEHRH1 | |
| SCHEMBL4846158 | 0.84 | BCHE (0.41) | MAOBBCHEACHEHRH1HDAC4 | |
| SCHEMBL4854696 | 0.84 | BCHE (0.41) | MAOBBCHEACHEHRH1HDAC4 | |
| SCHEMBL4848357 | 0.80 | MAOB (0.60) | MAOBBCHEACHEMAOAABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |