Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4857311 | 1.00 | BCHE (0.47) | BCHEACHESLC6A9ESR1HRH1 | |
| SCHEMBL4854696 | 0.91 | BCHE (0.41) | BCHEACHESLC6A9ESR1HRH1 | |
| SCHEMBL4846158 | 0.91 | BCHE (0.41) | BCHEACHESLC6A9ESR1HRH1 | |
| SCHEMBL4854959 | 0.89 | SLC6A9 (0.47) | BCHEACHESLC6A9ESR1HRH1 | |
| SCHEMBL4856397 | 0.89 | SLC6A9 (0.47) | BCHEACHESLC6A9ESR1HRH1 | |
| SCHEMBL5915433 | 0.88 | BCHE (0.48) | BCHE | |
| SCHEMBL5915846 | 0.88 | BCHE (0.48) | BCHE | |
| SCHEMBL4847371 | 0.88 | MAOB (0.52) | BCHEACHEHRH1 | |
| SCHEMBL4853434 | 0.84 | BCHE (0.51) | BCHEACHESLC6A9ESR1MCHR1 | |
| SCHEMBL4848110 | 0.84 | BCHE (0.51) | BCHEACHESLC6A9ESR1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| EP-1682486-A1 | QUATERNARY AMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2006-07-26 | — | — | EP | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |
| WO-2005042467-A1 | QUATERNARY AMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2005-05-12 | — | — | WO | disclosed |
| EP-1515940-A2 | AMINOALKOXY-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003097574-A2 | AMINOALKOXY-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |