Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 8/20 | 0.52 |
| ▸ | ACHE | P22303 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852919 | 0.85 | BCHE (0.56) | BCHEACHEKDM4EALDH1A1MAOB | |
| SCHEMBL4846048 | 0.81 | BCHE (0.56) | BCHEACHEKDM4EALDH1A1MAOB | |
| SCHEMBL4855074 | 0.80 | BCHE (0.52) | BCHEACHEKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4847485 | 0.80 | BCHE (0.52) | BCHEACHEKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4853057 | 0.76 | HRH1 (0.51) | BCHEACHEKDM4EALDH1A1MAOB | |
| SCHEMBL4856351 | 0.76 | HRH1 (0.51) | BCHEACHEKDM4EALDH1A1MAOB | |
| SCHEMBL4854761 | 0.75 | KDM4E (0.50) | BCHEACHEKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4854570 | 0.75 | HRH1 (0.41) | BCHEACHEKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4852988 | 0.74 | HRH1 (0.41) | BCHEACHEKDM4EALDH1A1MAOB | |
| SCHEMBL3686699 | 0.74 | HDAC3 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |