Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 6/20 | 0.56 |
| ▸ | ACHE | P22303 | 5/20 | 0.56 |
| ▸ | MAOB | P27338 | 10/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4846048 | 0.95 | BCHE (0.56) | BCHEACHEMAOBMAOAAPP | |
| SCHEMBL4853318 | 0.87 | MAOB (0.62) | BCHEACHEMAOBMAOAAPP | |
| SCHEMBL4847491 | 0.85 | BCHE (0.52) | BCHEACHEMAOBMAOAAPP | |
| SCHEMBL4848357 | 0.85 | MAOB (0.60) | BCHEACHEMAOBMAOAAPP | |
| SCHEMBL5915407 | 0.80 | HDAC4 (0.48) | BCHEMAOBMAOA | |
| SCHEMBL5915811 | 0.80 | HDAC4 (0.48) | BCHEMAOBMAOA | |
| SCHEMBL3685872 | 0.80 | MAOB (0.42) | BCHEACHEMAOBMAOA | |
| SCHEMBL4853057 | 0.80 | HRH1 (0.51) | BCHEACHEMAOBKDM4EALDH1A1 | |
| SCHEMBL4856351 | 0.80 | HRH1 (0.51) | BCHEACHEMAOBKDM4EALDH1A1 | |
| SCHEMBL4852227 | 0.80 | KDM4E (0.56) | BCHEACHEMAOBAPPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| EP-1515940-A2 | AMINOALKOXY-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-03-23 | — | — | EP | claimed |
| WO-2003097574-A2 | AMINOALKOXY-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |