Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | AR | P10275 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4856351 | 1.00 | HRH1 (0.51) | HRH1ARMAOBKDM4EALDH1A1 | |
| SCHEMBL4853062 | 0.92 | HRH1 (0.50) | HRH1ARMAOBKDM4EALDH1A1 | |
| SCHEMBL4852994 | 0.88 | PTGER1 (0.45) | HRH1ARMAOBKDM4EALDH1A1 | |
| SCHEMBL4854570 | 0.84 | HRH1 (0.41) | HRH1KDM4EALDH1A1BCHEACHE | |
| SCHEMBL4846157 | 0.84 | BCHE (0.42) | HRH1ARMAOBKDM4EALDH1A1 | |
| SCHEMBL6394376 | 0.84 | HTR7 (0.46) | HRH1ARMAOBKDM4EALDH1A1 | |
| SCHEMBL4852369 | 0.84 | HRH1 (0.41) | HRH1ARKDM4EALDH1A1BCHE | |
| SCHEMBL4851092 | 0.83 | ALDH1A1 (0.42) | HRH1ARKDM4EALDH1A1BCHE | |
| SCHEMBL4852988 | 0.83 | HRH1 (0.41) | HRH1ARMAOBKDM4EALDH1A1 | |
| SCHEMBL5915815 | 0.83 | BCHE (0.47) | ARMAOBKDM4EBCHENR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |