Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4856945 | 0.86 | TERT (0.54) | TERTRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL1669 | 0.81 | TERT (0.64) | TERTRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL1705329 | 0.81 | TERT (0.61) | TERTRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL8055439 | 0.76 | TERT (0.54) | TERTRAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL8055429 | 0.75 | TERT (0.56) | TERTRAB9ANPC1LMNANR1I2 | |
| SCHEMBL1792 | 0.75 | TERT (0.65) | TERTRAB9ANPC1LMNAL3MBTL1 | |
| SCHEMBL30357138 | 0.75 | TERT (0.65) | TERTRAB9ANPC1LMNAL3MBTL1 | |
| SCHEMBL8125815 | 0.74 | TERT (0.62) | TERTRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL6284529 | 0.73 | TERT (0.53) | TERTRAB9ANPC1LMNAHTT | |
| SCHEMBL8056309 | 0.72 | TERT (0.50) | TERTRAB9ALMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100886-A1 | PREPARATION AND USE OF DEUTERATED UDENAFIL ANALOGUES AS HIGHLY SELECTIVE PDE5 MODULATORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | disclosed |