Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 6/20 | 0.42 |
| ▸ | FPR1 | P21462 | 3/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL484193 | 0.90 | CYP3A4 (0.48) | TRPV1CYP3A4TSHRCYP1A2CYP2D6 | |
| SCHEMBL14988084 | 0.86 | CYP3A4 (0.42) | TRPV1CYP3A4TSHRCYP1A2CYP2D6 | |
| SCHEMBL484341 | 0.86 | CYP2C9 (0.43) | TRPV1CYP3A4TSHRCYP1A2CYP2D6 | |
| SCHEMBL484417 | 0.85 | CYP3A4 (0.45) | CYP3A4TSHRCYP1A2CYP2D6HIF1A | |
| SCHEMBL2816491 | 0.84 | CYP3A4 (0.44) | CYP3A4TSHRCYP1A2CYP2D6HIF1A | |
| SCHEMBL484486 | 0.84 | CYP3A4 (0.47) | CYP3A4TSHRCYP1A2CYP2D6HIF1A | |
| SCHEMBL484259 | 0.84 | CYP3A4 (0.43) | CYP3A4TSHRCYP1A2CYP2D6HIF1A | |
| SCHEMBL484980 | 0.83 | CYP3A4 (0.48) | CYP3A4TSHRCYP1A2CYP2D6HIF1A | |
| SCHEMBL484237 | 0.83 | CYP3A4 (0.44) | CYP3A4TSHRCYP1A2CYP2D6HIF1A | |
| SCHEMBL484920 | 0.83 | CYP3A4 (0.44) | CYP3A4TSHRCYP1A2CYP2D6HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | claimed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | claimed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | claimed |
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| EP-2411381-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-02-01 | — | — | EP | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
| WO-2010108651-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | TRPV1 331/4885CYP3A4 3781/4885TSHR 338/4885 |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | TRPV1 331/4885CYP3A4 3781/4885TSHR 338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.