Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852988 | 0.91 | HRH1 (0.41) | HRH1ABCB1ALDH1A1SMN1; SMN2BCHE | |
| SCHEMBL4847873 | 0.90 | HRH1 (0.39) | HRH1ABCB1ALDH1A1SMN1; SMN2BCHE | |
| SCHEMBL4849737 | 0.90 | HRH1 (0.39) | HRH1ABCB1ALDH1A1SMN1; SMN2BCHE | |
| SCHEMBL4854570 | 0.90 | HRH1 (0.41) | HRH1ALDH1A1SMN1; SMN2BCHEACHE | |
| SCHEMBL4853004 | 0.89 | HRH3 (0.40) | HRH1ALDH1A1SMN1; SMN2BCHEACHE | |
| SCHEMBL4847450 | 0.88 | SLC6A9 (0.43) | HRH1ALDH1A1SMN1; SMN2BCHEACHE | |
| SCHEMBL4850158 | 0.88 | SLC6A9 (0.41) | HRH1ALDH1A1SMN1; SMN2BCHEACHE | |
| SCHEMBL4852994 | 0.87 | PTGER1 (0.45) | HRH1ABCB1ALDH1A1SMN1; SMN2BCHE | |
| SCHEMBL4846157 | 0.87 | BCHE (0.42) | HRH1ALDH1A1BCHEACHEKDM4E | |
| SCHEMBL4846119 | 0.87 | KDM4E (0.40) | HRH1ALDH1A1SMN1; SMN2BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |