Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 15/20 | 0.39 |
| ▸ | PPARG | P37231 | 13/20 | 0.39 |
| ▸ | PPARD | Q03181 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4848609 | 0.86 | TSHR (0.39) | TSHRALDH1A1PPARAPPARGPPARD | |
| SCHEMBL4850282 | 0.81 | FFAR1 (0.56) | KDRPPARAPPARGPPARD | |
| SCHEMBL4848598 | 0.81 | TSHR (0.34) | TSHRALDH1A1KDRPPARAPPARG | |
| SCHEMBL6606425 | 0.74 | KDM4E (0.49) | TSHRALDH1A1KDRPPARAPPARG | |
| SCHEMBL5474356 | 0.73 | L3MBTL1 (0.38) | KDM4E | |
| SCHEMBL3587800 | 0.73 | PPARA (0.52) | PPARAPPARGPPARDKDM4E | |
| SCHEMBL4034186 | 0.72 | PPARA (0.47) | TSHRALDH1A1KDRPPARAPPARG | |
| SCHEMBL4845525 | 0.71 | KDR (0.66) | KDRPPARAPPARG | |
| SCHEMBL8777276 | 0.71 | KCNH2 (0.41) | — | |
| SCHEMBL4822404 | 0.70 | PDCD1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368578-B2 | Five-membered heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-06 | — | — | US | disclosed |
| US-20060135578-A1 | Five-membered heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-06-22 | — | — | US | disclosed |
| EP-1541564-A1 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2005-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135578-A1 | Five-membered heterocyclic compounds | GPR119, OR10J3, CYP11B1 | TSHR 2067/4885ALDH1A1 821/4885KDR 2335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.