Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6141493 | 1.00 | SLC6A9 (0.42) | SLC6A9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4845759 | 0.91 | ABCG2 (0.47) | SLC6A9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4854857 | 0.91 | ABCG2 (0.47) | SLC6A9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4849336 | 0.91 | TNFRSF1A (0.44) | SLC6A9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4853568 | 0.90 | SLC6A9 (0.46) | SLC6A9SMN1; SMN2ESR1BCHEACHE | |
| SCHEMBL4847435 | 0.90 | SLC6A9 (0.46) | SLC6A9SMN1; SMN2ESR1BCHEACHE | |
| SCHEMBL4852348 | 0.87 | SLC6A9 (0.45) | SLC6A9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4856317 | 0.87 | ABCG2 (0.46) | SLC6A9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4848486 | 0.87 | SLC6A9 (0.45) | SLC6A9PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4848031 | 0.87 | ABCG2 (0.46) | SLC6A9PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |