Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4845759 | 1.00 | ABCG2 (0.47) | ABCG2SLC6A9PDE4APDE4BPDE4C | |
| SCHEMBL4845764 | 0.91 | ABCG2 (0.46) | ABCG2SLC6A9PDE4APDE4BPDE4C | |
| SCHEMBL4849331 | 0.91 | SLC6A9 (0.42) | ABCG2SLC6A9PDE4APDE4BPDE4C | |
| SCHEMBL6141493 | 0.91 | SLC6A9 (0.42) | ABCG2SLC6A9PDE4APDE4BPDE4C | |
| SCHEMBL4848103 | 0.90 | SLC6A9 (0.47) | ABCG2SLC6A9KDM4ESMN1; SMN2 | |
| SCHEMBL4852269 | 0.90 | SLC6A9 (0.47) | ABCG2SLC6A9KDM4ESMN1; SMN2 | |
| SCHEMBL4854239 | 0.88 | SLC6A9 (0.46) | ABCG2SLC6A9KDM4ELMNAMAPT | |
| SCHEMBL4848047 | 0.88 | SLC6A9 (0.46) | ABCG2SLC6A9KDM4ELMNAMAPT | |
| SCHEMBL4854688 | 0.86 | TUBB4A (0.48) | ABCG2SLC6A9MAOBMAPTTNFRSF1A | |
| SCHEMBL4851437 | 0.86 | TUBB4A (0.48) | ABCG2SLC6A9MAOBMAPTTNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |