Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | WNT3A | P56704 | 4/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4845162 | 0.97 | NOTUM (0.42) | SMN1; SMN2ALDH1A1MAPTATML3MBTL1 | |
| SCHEMBL4843095 | 0.91 | MAPT (0.43) | SMN1; SMN2ALDH1A1MAPTATML3MBTL1 | |
| SCHEMBL4843277 | 0.88 | NOTUM (0.41) | SMN1; SMN2ALDH1A1MAPTATML3MBTL1 | |
| SCHEMBL4880708 | 0.85 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1MAPTATML3MBTL1 | |
| SCHEMBL14021730 | 0.84 | MAPT (0.42) | SMN1; SMN2ALDH1A1MAPTATML3MBTL1 | |
| SCHEMBL14021731 | 0.83 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1MAPTATML3MBTL1 | |
| SCHEMBL4848359 | 0.83 | CYSLTR1 (0.50) | — | |
| SCHEMBL4841446 | 0.83 | CYSLTR1 (0.47) | — | |
| SCHEMBL4850064 | 0.82 | CYSLTR1 (0.49) | — | |
| SCHEMBL4847061 | 0.81 | MAPT (0.40) | SMN1; SMN2ALDH1A1MAPTATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE40558-E1 | Therapeutic uses of di-aryl acid derivatives | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-6635655-B1 | Agonists or antagonists of peroxisome proliferator-activated receptors | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-10-21 | — | — | US | disclosed |