Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705429 | 0.87 | GAA (0.61) | POLBALDH1A1KDM4ELMNA | |
| SCHEMBL4849754 | 0.86 | POLB (0.64) | POLBHTR2AALDH1A1KDM4ETSHR | |
| SCHEMBL7131206 | 0.84 | KDM4E (0.78) | POLBALDH1A1KDM4ETSHRUSP2 | |
| SCHEMBL42206 | 0.83 | ACHE (0.67) | HTR2AALDH1A1 | |
| SCHEMBL4849748 | 0.79 | POLB (0.56) | POLBHTR2AALDH1A1KDM4ETSHR | |
| SCHEMBL7461917 | 0.77 | TSHR (0.72) | ALDH1A1KDM4ETSHRLMNA | |
| SCHEMBL14470092 | 0.76 | MEN1 (0.81) | POLBALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL5249650 | 0.75 | MEN1 (0.77) | POLBALDH1A1KDM4ETSHRLMNA | |
| SCHEMBL3974277 | 0.74 | LMNA (0.73) | ALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL8036144 | 0.74 | LMNA (0.73) | ALDH1A1TSHRLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432379-B2 | Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2008-10-07 | — | — | US | claimed |