⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19033746 | 1.00 | — | — | |
| SCHEMBL6859432 | 0.84 | — | — | |
| Water SCHEMBL31742532 | 0.81 | ALDH1A1 (0.33) | — | |
| SCHEMBL1268268 | 0.81 | ALDH1A1 (0.33) | — | |
| SCHEMBL28593199 | 0.81 | ALDH1A1 (0.33) | — | |
| SCHEMBL7808507 | 0.80 | — | — | |
| SCHEMBL16083906 | 0.80 | — | — | |
| SCHEMBL14440873 | 0.79 | CTSS (0.33) | — | |
| SCHEMBL9755816 | 0.78 | TSHR (0.33) | — | |
| SCHEMBL31346428 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228506-A1 | RIPK1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-07-11 | — | — | US | disclosed |
| EP-4329766-A1 | RIPK1 INHIBITORS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2024-03-06 | — | — | EP | disclosed |
| CN-114044743-B | Preparation method of ethyl 2-cyanopropionate | 西安凯立新材料股份有限公司 | 2023-10-17 | — | — | CN | disclosed |
| WO-2022231928-A1 | RIPK1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2022-11-03 | — | — | WO | disclosed |
| EP-3079701-B1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME (US) | 2021-08-11 | — | — | EP | disclosed |
| US-10889589-B2 | Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain | ARRAY BIOPHARMA INC. (US) | 2021-01-12 | — | — | US | disclosed |
| CN-107602584-B | Compound for organic electric element, organic electric element using same, and electronic device using same | 德山新勒克斯有限公司 | 2020-11-03 | — | — | CN | disclosed |
| US-20190270749-A1 | BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN | ARRAY BIOPHARMA INC. (US) | 2019-09-05 | — | — | US | disclosed |
| US-10351575-B2 | Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain | ARRAY BIOPHARMA INC. (US) | 2019-07-16 | — | — | US | disclosed |
| US-10323022-B2 | Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as TrkA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2019-06-18 | — | — | US | disclosed |
| EP-0741127-B1 | Synthesis of cyanoacrylate esters by oxidation of aromatic selenyl cyanopropionates | LOCTITE CORP (US) | 1999-04-07 | — | — | EP | disclosed |
| CN-1212722-A | Cold accumulation material for ultra-low temp., refrigerating machine using the material and heat shield material | TOSHIBA KK (JP) | 1999-03-31 | — | — | CN | disclosed |
| WO-1998059108-A2 | OXIDATION AND BLEACHING SYSTEM WITH ENZYMATICALLY PRODUCED OXIDIZING AGENTS | BLUME, HILDEGARD (DE) | 1998-12-30 | — | — | WO | disclosed |
| WO-1998016826-A1 | IMMUNOASSAY FOR THE DETECTION AND MEASUREMENT OF 2,2-DIBROMO-3-NITRILOPROPIONAMIDE | THE DOW CHEMICAL COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |
| EP-0741127-A1 | Synthesis of cyanoacrylate esters by oxidation of aromatic selenyl cyanopropionates | LOCTITE CORPORATION (US) | 1996-11-06 | — | — | EP | disclosed |
| US-5504252-A | Synthesis of cyanoacrylate esters by oxidation of aromatic selenyl cyanopropionates | LOCTITE CORPORATION (US) | 1996-04-02 | — | — | US | disclosed |
| EP-0290570-B1 | CHIRAL OR ACHIRAL CYCLIC COMPOUNDS | MERCK PATENT GmbH (DE) | 1992-09-23 | — | — | EP | disclosed |
| EP-0290570-A1 | CHIRAL OR ACHIRAL CYCLIC COMPOUNDS. | MERCK PATENT GMBH (DE) | 1988-11-17 | — | — | EP | disclosed |
| WO-1988003530-A1 | CHIRAL OR ACHIRAL CYCLIC COMPOUNDS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1988-05-19 | — | — | WO | disclosed |
| US-4299979-A | CORROSION RESISTANT COATING | DESOTO, INC. (US) | 1981-11-10 | — | — | US | disclosed |