Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852586 | 1.00 | HTR7 (0.46) | HTR7ALDH1A1KDM4ESMN1; SMN2SLC6A9 | |
| SCHEMBL4846136 | 0.92 | MAPT (0.45) | SMN1; SMN2BCHEACHE | |
| SCHEMBL4857401 | 0.92 | MAPT (0.45) | SMN1; SMN2BCHEACHE | |
| SCHEMBL4853913 | 0.91 | MAPT (0.44) | ALDH1A1SMN1; SMN2MCHR1 | |
| SCHEMBL4852385 | 0.91 | MAPT (0.44) | ALDH1A1SMN1; SMN2MCHR1 | |
| SCHEMBL4846148 | 0.91 | ALDH1A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2BCHEACHE | |
| SCHEMBL4852887 | 0.91 | ALDH1A1 (0.42) | ALDH1A1KDM4ESMN1; SMN2BCHEACHE | |
| SCHEMBL4852630 | 0.91 | ALDH1A1 (0.41) | HTR7ALDH1A1KDM4ESMN1; SMN2SLC6A9 | |
| SCHEMBL4851088 | 0.91 | ALDH1A1 (0.41) | HTR7ALDH1A1KDM4ESMN1; SMN2SLC6A9 | |
| SCHEMBL4849707 | 0.90 | KDM4E (0.39) | HTR7ALDH1A1KDM4ESMN1; SMN2SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |