Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566719 | 0.80 | NPC1 (0.72) | CYP2C19POLBNPC1RAB9AMEN1 | |
| SCHEMBL4845542 | 0.78 | ALDH1A1 (0.44) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL29097833 | 0.78 | TAAR1 (0.60) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL5767226 | 0.78 | MEN1 (0.43) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL31381443 | 0.77 | MEN1 (0.67) | CYP2C19POLBNPC1RAB9AMEN1 | |
| SCHEMBL908565 | 0.77 | MEN1 (0.58) | CYP2C19POLBNPC1RAB9AMEN1 | |
| SCHEMBL7647604 | 0.77 | MEN1 (0.67) | CYP2C19POLBNPC1RAB9AMEN1 | |
| SCHEMBL29923859 | 0.77 | MEN1 (0.58) | CYP2C19POLBNPC1RAB9AMEN1 | |
| SCHEMBL6961760 | 0.76 | NPC1 (0.80) | CYP2C19POLBNPC1RAB9AMEN1 | |
| SCHEMBL14278971 | 0.76 | CYP2C19 (0.71) | CYP2C19POLBNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7323458-B1 | Dihydrobenzodiazepins and their use for treating dyslipidemia | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-01-29 | — | — | US | disclosed |
| EP-1189890-B1 | DIHYDROBENZODIAZEPINS AND THEIR USE FOR TREATING DYSLIPIDEMIA | MERCK PATENT GMBH (DE) | 2006-04-19 | — | — | EP | disclosed |
| EP-1189890-A1 | DIHYDROBENZODIAZEPINS AND THEIR USE FOR TREATING DYSLIPIDEMIA | MERCK PATENT GmbH (DE) | 2002-03-27 | — | — | EP | disclosed |
| WO-2001002373-A1 | DIHYDROBENZODIAZEPINS AND THEIR USE FOR TREATING DYSLIPIDEMIA | MERCK PATENT GMBH (DE) | 2001-01-11 | — | — | WO | disclosed |