Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5767226 | 0.82 | MEN1 (0.43) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL29097833 | 0.82 | TAAR1 (0.60) | ALDH1A1HPGDMEN1KMT2ANPC1 | |
| SCHEMBL10700966 | 0.78 | NPC1 (0.55) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL4850673 | 0.78 | CYP2C19 (0.63) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL2310135 | 0.76 | MEN1 (0.49) | ALDH1A1HPGDMEN1KMT2ANPC1 | |
| SCHEMBL27973340 | 0.76 | KMT2A (0.52) | ALDH1A1HPGDMEN1KMT2ANPC1 | |
| SCHEMBL17462497 | 0.75 | MEN1 (0.48) | ALDH1A1HPGDMEN1KMT2ANPC1 | |
| SCHEMBL22316651 | 0.74 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4ERCE1HCRTR2 | |
| SCHEMBL644296 | 0.74 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4ERCE1MEN1 | |
| SCHEMBL14278969 | 0.73 | TAAR1 (0.42) | ALDH1A1HPGDKDM4ERCE1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7323458-B1 | Dihydrobenzodiazepins and their use for treating dyslipidemia | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-01-29 | — | — | US | disclosed |
| EP-1189890-A1 | DIHYDROBENZODIAZEPINS AND THEIR USE FOR TREATING DYSLIPIDEMIA | MERCK PATENT GmbH (DE) | 2002-03-27 | — | — | EP | disclosed |
| WO-2001002373-A1 | DIHYDROBENZODIAZEPINS AND THEIR USE FOR TREATING DYSLIPIDEMIA | MERCK PATENT GMBH (DE) | 2001-01-11 | — | — | WO | disclosed |