Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.64 |
| ▸ | CDC25B | P30305 | 2/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.64 |
| ▸ | COPS5 | Q92905 | 2/20 | 0.64 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.64 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.64 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | USP2 | O75604 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | THRB | P10828 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthazalin SCHEMBL149279 | 0.78 | TXNRD1 (1.00) | AURKACDC25BAURKBCOPS5TXNRD1 | |
| Naphthazalin SCHEMBL29353283 | 0.78 | TXNRD1 (1.00) | AURKACDC25BAURKBCOPS5TXNRD1 | |
| Naphthazalin SCHEMBL27700955 | 0.78 | TXNRD1 (1.00) | AURKACDC25BAURKBCOPS5TXNRD1 | |
| Naphthazalin SCHEMBL6122890 | 0.76 | TXNRD1 (0.94) | AURKACDC25BAURKBCOPS5TXNRD1 | |
| Naphthazalin SCHEMBL21403377 | 0.76 | TXNRD1 (0.94) | AURKACDC25BAURKBCOPS5TXNRD1 | |
| SCHEMBL9643081 | 0.73 | MAPT (0.52) | AURKACDC25BAURKBCOPS5TXNRD1 | |
| SCHEMBL17464265 | 0.73 | PIM1 (0.50) | AURKACDC25BAURKBCOPS5TXNRD1 | |
| SCHEMBL3447098 | 0.73 | ALDH1A1 (0.52) | AURKACDC25BAURKBCOPS5TXNRD1 | |
| SCHEMBL30695845 | 0.71 | CDC25B (0.58) | AURKACDC25BAURKBCOPS5TXNRD1 | |
| SCHEMBL5299235 | 0.71 | CDC25B (0.58) | AURKACDC25BAURKBCOPS5TXNRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008062252-A1 | N-OXIDES OF CYTOTOXIC ANTHRAQUINONES AS HYPOXIA-TARGETING PRODRUGS IN CANCER TREATMENT | ACCESS PHARMACEUTICALS, INC (US) | 2008-05-29 | — | — | WO | disclosed |
| US-20070208085-A1 | Potent cytotoxicity and inhibition of pan-cell cycle progression by an alkylating anthraquinone | SOMANTA LIMITED (GB) | 2007-09-06 | — | — | US | disclosed |
| WO-2007083114-A1 | ALCHEMIX FOR THE TREATMENT OF CANCER | SOMANTA, INCORPORATED (US) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208085-A1 | Potent cytotoxicity and inhibition of pan-cell cycle progression by an alkylating anthraquinone | BOD1L1, CDC25C, CCNI | AURKA 61/4885CDC25B 5/4885AURKB 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.