Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853461 | 1.00 | AR (0.48) | ARSLC6A9SMN1; SMN2LMNAMAPT | |
| SCHEMBL4852241 | 0.93 | SLC6A9 (0.45) | ARSLC6A9SMN1; SMN2LMNAMAPT | |
| SCHEMBL4853568 | 0.88 | SLC6A9 (0.46) | ARSLC6A9SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4847435 | 0.88 | SLC6A9 (0.46) | ARSLC6A9SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4845755 | 0.88 | AR (0.49) | ARSLC6A9SMN1; SMN2LMNAMAPT | |
| SCHEMBL4853937 | 0.88 | AR (0.49) | ARSLC6A9SMN1; SMN2LMNAMAPT | |
| SCHEMBL4855044 | 0.85 | SLC6A9 (0.46) | ARSLC6A9SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4854689 | 0.85 | SLC6A9 (0.46) | ARSLC6A9SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4850162 | 0.85 | CHRNA7 (0.51) | SLC6A9SMN1; SMN2LMNAALDH1A1HTR7 | |
| SCHEMBL4853325 | 0.85 | CHRNA7 (0.51) | SLC6A9SMN1; SMN2LMNAALDH1A1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |