Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.53 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 4/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853707 | 1.00 | TUBB1 (0.53) | TUBB1TNFRSF1ABCHEACHEKDM4E | |
| SCHEMBL4854973 | 0.90 | MCL1 (0.50) | TUBB1TNFRSF1ABCHEACHEKDM4E | |
| SCHEMBL4856299 | 0.90 | MCL1 (0.50) | TUBB1TNFRSF1ABCHEACHEKDM4E | |
| SCHEMBL4847824 | 0.87 | TUBB1 (0.55) | TUBB1TNFRSF1ABCHEACHEMCL1 | |
| SCHEMBL4853445 | 0.87 | TUBB1 (0.55) | TUBB1TNFRSF1ABCHEACHEMCL1 | |
| SCHEMBL4849818 | 0.85 | KDM4E (0.51) | BCHEACHEKDM4EMCL1LMNA | |
| SCHEMBL4849756 | 0.85 | KDM4E (0.51) | BCHEACHEKDM4EMCL1LMNA | |
| SCHEMBL4847380 | 0.83 | KDM4E (0.45) | TNFRSF1AKDM4EMEN1KMT2ALMNA | |
| SCHEMBL4847751 | 0.83 | TUBB1 (0.51) | TUBB1TNFRSF1ABCHEACHEMCL1 | |
| SCHEMBL4848181 | 0.83 | KDM4E (0.45) | TNFRSF1AKDM4EMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |