Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 2/20 | 0.40 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854973 | 1.00 | MCL1 (0.50) | MCL1KDM4EESR1BCHEACHE | |
| SCHEMBL4852536 | 0.90 | TUBB1 (0.53) | MCL1KDM4EBCHEACHEMEN1 | |
| SCHEMBL4853707 | 0.90 | TUBB1 (0.53) | MCL1KDM4EBCHEACHEMEN1 | |
| SCHEMBL4853541 | 0.87 | MCL1 (0.53) | MCL1BCHEACHEKMT2AMAOB | |
| SCHEMBL4854223 | 0.87 | MCL1 (0.53) | MCL1BCHEACHEKMT2AMAOB | |
| SCHEMBL4849818 | 0.87 | KDM4E (0.51) | MCL1KDM4EBCHEACHELMNA | |
| SCHEMBL4849756 | 0.87 | KDM4E (0.51) | MCL1KDM4EBCHEACHELMNA | |
| SCHEMBL4847316 | 0.83 | MCL1 (0.48) | MCL1BCHEACHEMEN1LMNA | |
| SCHEMBL4851370 | 0.83 | MCL1 (0.48) | MCL1BCHEACHEMEN1LMNA | |
| SCHEMBL4854982 | 0.82 | KDM4E (0.47) | KDM4EESR1BCHEACHESNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |