Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 2/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 5/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 4/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853354 | 1.00 | SLC6A9 (0.40) | SLC6A9PTPN11KEAP1NFE2L2MAOA | |
| SCHEMBL4853380 | 0.99 | SLC6A9 (0.40) | SLC6A9PTPN11KEAP1NFE2L2MAOA | |
| SCHEMBL4854641 | 0.99 | SLC6A9 (0.40) | SLC6A9PTPN11KEAP1NFE2L2MAOA | |
| SCHEMBL4852352 | 0.95 | SLC6A9 (0.43) | SLC6A9PTPN11KEAP1NFE2L2KDM4E | |
| SCHEMBL4847208 | 0.95 | SLC6A9 (0.43) | SLC6A9PTPN11KEAP1NFE2L2KDM4E | |
| SCHEMBL4854469 | 0.92 | SLC6A9 (0.43) | SLC6A9PTPN11KDM4EALDH1A1BCHE | |
| SCHEMBL4856457 | 0.92 | SLC6A9 (0.43) | SLC6A9PTPN11KDM4EALDH1A1BCHE | |
| SCHEMBL4852923 | 0.91 | SLC6A9 (0.37) | SLC6A9PTPN11KEAP1NFE2L2MAOA | |
| SCHEMBL4853384 | 0.90 | PTPN11 (0.37) | SLC6A9PTPN11MAOAMAOBAPP | |
| SCHEMBL4853574 | 0.90 | SLC6A9 (0.43) | SLC6A9PTPN11KDM4EALDH1A1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| EP-1515940-A2 | AMINOALKOXY-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-03-23 | — | — | EP | claimed |
| WO-2003097574-A2 | AMINOALKOXY-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |