Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | PI4KA | P42356 | 1/20 | 0.47 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.47 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29907282 | 0.83 | L3MBTL1 (0.55) | CYP11B1CYP11B2LMNAADORA2AHTT | |
| SCHEMBL4566468 | 0.81 | CYP11B1 (0.58) | CYP11B1CYP11B2TNFHTR6LMNA | |
| SCHEMBL3788877 | 0.81 | CYP11B1 (0.58) | CYP11B1CYP11B2TNFHTR6LMNA | |
| SCHEMBL229001 | 0.81 | LMNA (0.59) | CYP11B1CYP11B2TNFHTR6LMNA | |
| SCHEMBL17596372 | 0.78 | CYP11B1 (0.55) | CYP11B1CYP11B2TNFHTR6LMNA | |
| SCHEMBL12970517 | 0.78 | GRM2 (0.51) | GRM2ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL23293667 | 0.77 | CYP11B1 (0.54) | CYP11B1CYP11B2TNFHTR6LMNA | |
| SCHEMBL4551517 | 0.77 | CYP11B1 (0.54) | CYP11B1CYP11B2TNFHTR6LMNA | |
| SCHEMBL7025928 | 0.77 | LMNA (0.52) | CYP11B1CYP11B2TNFHTR6LMNA | |
| SCHEMBL4551518 | 0.77 | CYP11B1 (0.54) | CYP11B1CYP11B2TNFHTR6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | CYP11B1 2685/4885CYP11B2 2636/4885TNF 4821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.