Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | NFATC1 | O95644 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4857531 | 0.83 | DYRK1A (0.66) | DYRK1AKDM4CKCNH2CDK2DYRK1B | |
| SCHEMBL29801631 | 0.83 | DYRK1A (0.66) | DYRK1AKDM4CKCNH2CDK2DYRK1B | |
| SCHEMBL21917355 | 0.80 | DYRK1A (0.44) | DYRK1AKDM4CKCNH2CNR1CNR2 | |
| SCHEMBL4852904 | 0.80 | CNR2 (0.48) | DYRK1AKDM4CKCNH2CNR1CNR2 | |
| SCHEMBL4855991 | 0.78 | DYRK1A (0.51) | DYRK1AKDM4CKCNH2NFATC1GSK3B | |
| SCHEMBL4856807 | 0.77 | CNR1 (0.44) | DYRK1AKDM4CKCNH2CNR1CNR2 | |
| SCHEMBL4856451 | 0.77 | LTA4H (0.49) | DYRK1AKDM4CCNR2NFATC1GSK3B | |
| SCHEMBL4858180 | 0.77 | DYRK1A (0.46) | DYRK1AKDM4CKCNH2CNR1CNR2 | |
| SCHEMBL21917169 | 0.77 | DYRK1A (0.56) | DYRK1AKDM4CKCNH2CNR1CNR2 | |
| SCHEMBL4849408 | 0.76 | DYRK1A (0.53) | DYRK1AKDM4CKCNH2CDK2DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | DYRK1A 1117/4885KDM4C 1604/4885KCNH2 2535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.