Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4856202 | 0.85 | TBXAS1 (0.50) | LTA4HTBXAS1NFATC1GSK3BDYRK1A | |
| SCHEMBL32691572 | 0.81 | DYRK1A (0.67) | NFATC1GSK3BDYRK1AKDM4CCNR2 | |
| SCHEMBL21917167 | 0.81 | DYRK1A (0.67) | NFATC1GSK3BDYRK1AKDM4CCNR2 | |
| SCHEMBL4854988 | 0.81 | CYP1A2 (0.46) | NFATC1GSK3BDYRK1AKMT2AKDM4E | |
| SCHEMBL4851778 | 0.78 | DYRK1A (0.50) | NFATC1GSK3BDYRK1AKDM4CCNR2 | |
| SCHEMBL4855827 | 0.77 | DYRK1A (0.47) | NFATC1GSK3BDYRK1AKDM4CCNR2 | |
| SCHEMBL4856807 | 0.76 | CNR1 (0.44) | NFATC1GSK3BDYRK1AKDM4CCNR2 | |
| SCHEMBL29801631 | 0.76 | DYRK1A (0.66) | TBXAS1NFATC1GSK3BDYRK1AKDM4C | |
| SCHEMBL4857531 | 0.76 | DYRK1A (0.66) | TBXAS1NFATC1GSK3BDYRK1AKDM4C | |
| SCHEMBL4858180 | 0.76 | DYRK1A (0.46) | NFATC1GSK3BDYRK1AKDM4CCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | LTA4H 3439/4885TBXAS1 518/4885NFATC1 1618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.