Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.47 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4857279 | 0.89 | CHRNA7 (0.49) | KDM4ETUBB1CHRNA7ALOX5CYP1A1 | |
| SCHEMBL4855889 | 0.89 | CHRNA7 (0.49) | KDM4ETUBB1CHRNA7ALOX5CYP1A1 | |
| SCHEMBL4852831 | 0.87 | TUBB1 (0.50) | KDM4ETUBB1TNFRSF1ACHRNA7ALOX5 | |
| SCHEMBL4846217 | 0.87 | CHRNA7 (0.58) | TUBB1TNFRSF1ACHRNA7ALOX5MCL1 | |
| SCHEMBL4849390 | 0.84 | ALDH1A1 (0.52) | KDM4ETUBB1TNFRSF1ACHRNA7ALOX5 | |
| SCHEMBL4847397 | 0.83 | LMNA (0.49) | KDM4ECYP1A1CYP1B1PDE4APDE4B | |
| SCHEMBL4845551 | 0.83 | MCHR1 (0.49) | KDM4ETUBB1TNFRSF1ACHRNA7ALOX5 | |
| SCHEMBL4851981 | 0.82 | CHRNA7 (0.46) | TUBB1TNFRSF1ACHRNA7ALOX5MCL1 | |
| SCHEMBL4845636 | 0.82 | TNFRSF1A (0.49) | KDM4ETUBB1TNFRSF1ACHRNA7ALOX5 | |
| SCHEMBL4852544 | 0.81 | KDM4E (0.47) | KDM4ETUBB1CYP1A1CYP1B1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |