SCHEMBL485675

SCHEMBL485675

N#Cc1cccc(CC(NS(=O)(=O)c2ccccc2)C(=O)O)c1

nearest known ligand 0.66

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 9/20 0.66
MMP9 P14780 7/20 0.66
ADAMTS4 O75173 3/20 0.61
MMP13 P45452 3/20 0.55
ADAMTS5 Q9UNA0 1/20 0.55
ALDH1A1 P00352 1/20 0.55
MAPT P10636 1/20 0.55
POLB P06746 1/20 0.55
MMP1 P03956 1/20 0.55
MMP3 P08254 1/20 0.55
MMP7 P09237 1/20 0.55
ITGAV P06756 1/20 0.53
CTSL P07711 2/20 0.51
CTSS P25774 2/20 0.51
CTSK P43235 2/20 0.51
CTSB P07858 1/20 0.51
CNR1 P21554 1/20 0.50
CNR2 P34972 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL485678 1.00 MMP2 (0.66) MMP2MMP9ADAMTS4MMP13ADAMTS5
SCHEMBL18049268 0.91 MMP2 (0.61) MMP2MMP9ADAMTS4MMP13ADAMTS5
SCHEMBL19923004 0.91 MMP2 (0.61) MMP2MMP9ADAMTS4MMP13ADAMTS5
SCHEMBL8195568 0.90 MMP2 (0.54) MMP2MMP9ADAMTS4MMP13ADAMTS5
SCHEMBL8197720 0.90 MMP2 (0.54) MMP2MMP9ADAMTS4MMP13ADAMTS5
SCHEMBL12811750 0.90 MMP2 (0.54) MMP2MMP9ADAMTS4MMP13ADAMTS5
SCHEMBL30376399 0.90 MMP2 (0.54) MMP2MMP9ADAMTS4MMP13ADAMTS5
SCHEMBL18049375 0.89 MMP2 (0.58) MMP2MMP9ADAMTS4MMP13ADAMTS5
SCHEMBL7566084 0.89 MMP2 (0.58) MMP2MMP9ADAMTS4MMP13ADAMTS5
SCHEMBL29024842 0.87 MMP2 (0.50) MMP2MMP9ADAMTS4MMP13ITGAV

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2132174-A1 META-SUBSTITUTED PHENYL SULFONYL AMIDES OF SECONDARY AMINO ACID AMIDES, THE PRODUCTION THEREOF, AND USE THEREOF AS MATRIPTASE INHIBITORS The Medicines Company (Leipzig) GmbH (DE) 2009-12-16 EP claimed
WO-2008107176-A1 META-SUBSTITUTED PHENYL SULFONYL AMIDES OF SECONDARY AMINO ACID AMIDES, THE PRODUCTION THEREOF, AND USE THEREOF AS MATRIPTASE INHIBITORS THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) 2008-09-12 WO claimed
CN-116323572-A 3- (2- (benzo [ D ] thiazol-2-yl) -2- (phenylsulfonylamino) ethyl) benzamide derivatives and related compounds as TMPRSS2 inhibitors for the treatment of viral infections 塔斯宾医疗公司 2023-06-23 CN disclosed
EP-4157825-A1 3-(2-(BENZO[D]THIAZOL-2-YL)-2-(PHENYLSUFONAMIDO)ETHYL)BENZIMIDAMIDE DERIVATIVES AND RELATED COMPOUNDS AS TMPRSS2 INHIBITORS FOR THE TREATMENT OF VIRAL INFECTIONS Topspin Therapeutics, Inc. (US) 2023-04-05 EP disclosed
EP-2132174-B1 META-SUBSTITUTED PHENYL SULFONYL AMIDES OF SECONDARY AMINO ACID AMIDES, THE PRODUCTION THEREOF, AND USE THEREOF AS MATRIPTASE INHIBITORS MEDICINES CO LEIPZIG GMBH (DE) 2012-02-01 EP disclosed
EP-2132174-A1 META-SUBSTITUTED PHENYL SULFONYL AMIDES OF SECONDARY AMINO ACID AMIDES, THE PRODUCTION THEREOF, AND USE THEREOF AS MATRIPTASE INHIBITORS The Medicines Company (Leipzig) GmbH (DE) 2009-12-16 EP disclosed
WO-2008107176-A1 META-SUBSTITUTED PHENYL SULFONYL AMIDES OF SECONDARY AMINO ACID AMIDES, THE PRODUCTION THEREOF, AND USE THEREOF AS MATRIPTASE INHIBITORS THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) 2008-09-12 WO disclosed