Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.61 |
| ▸ | MMP9 | P14780 | 8/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.56 |
| ▸ | MMP13 | P45452 | 3/20 | 0.55 |
| ▸ | MMP3 | P08254 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18049268 | 1.00 | MMP2 (0.61) | MMP2MMP9TDP1POLBADAMTS4 | |
| SCHEMBL485675 | 0.91 | MMP2 (0.66) | MMP2MMP9POLBADAMTS4MMP13 | |
| SCHEMBL485678 | 0.91 | MMP2 (0.66) | MMP2MMP9POLBADAMTS4MMP13 | |
| SCHEMBL29682731 | 0.89 | PLAU (0.53) | MMP2MMP9TDP1POLBADAMTS4 | |
| SCHEMBL7450718 | 0.88 | CTSL (0.52) | MMP2MMP9TDP1POLBADAMTS4 | |
| SCHEMBL28690184 | 0.86 | TDP1 (0.72) | MMP2MMP9TDP1POLBADAMTS4 | |
| SCHEMBL28690186 | 0.86 | TDP1 (0.72) | MMP2MMP9TDP1POLBADAMTS4 | |
| SCHEMBL18049255 | 0.85 | PLAU (0.61) | — | |
| SCHEMBL7566084 | 0.85 | MMP2 (0.58) | MMP2MMP9POLBADAMTS4MMP13 | |
| SCHEMBL18049375 | 0.85 | MMP2 (0.58) | MMP2MMP9POLBADAMTS4MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169676-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | WASHINGTON UNIVERSITY (US) | 2022-06-02 | — | — | US | disclosed |
| US-11130780-B2 | Inhibitors of growth factor activation enzymes | WASHINGTON UNIVERSITY (US) | 2021-09-28 | — | — | US | disclosed |
| US-20180066015-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | WASHINGTON UNIVERSITY (US) | 2018-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11130780-B2 | Inhibitors of growth factor activation enzymes | HDGF, MMP7, HGF | MMP2 56/4885MMP9 52/4885TDP1 2106/4885 |
| US-20220169676-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | HDGF, MMP7, HGF | MMP2 56/4885MMP9 52/4885TDP1 2106/4885 |
| US-20180066015-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | HDGF, MMP7, HGF | MMP2 56/4885MMP9 52/4885TDP1 2106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.