Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.47 |
| ▸ | SENP5 | Q96HI0 | 18/20 | 0.45 |
| ▸ | SENP2 | Q9HC62 | 18/20 | 0.45 |
| ▸ | SENP1 | Q9P0U3 | 18/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485081 | 0.90 | CXCR2 (0.48) | CXCR2SENP5SENP2SENP1USP2 | |
| SCHEMBL485276 | 0.89 | CXCR2 (0.61) | CXCR2SENP5SENP2SENP1USP2 | |
| SCHEMBL485073 | 0.83 | CXCR2 (0.61) | CXCR2 | |
| SCHEMBL485820 | 0.81 | CXCR2 (0.45) | CXCR2 | |
| SCHEMBL485260 | 0.77 | SENP2 (0.56) | CXCR2SENP5SENP2SENP1USP2 | |
| SCHEMBL485845 | 0.77 | CXCR2 (0.46) | CXCR2SENP5SENP2SENP1USP2 | |
| SCHEMBL485715 | 0.77 | SENP5 (0.39) | CXCR2SENP5SENP2SENP1USP2 | |
| SCHEMBL485351 | 0.77 | CXCR2 (0.56) | CXCR2 | |
| SCHEMBL485458 | 0.76 | CXCR2 (0.64) | CXCR2SENP5SENP2SENP1USP2 | |
| SCHEMBL485732 | 0.74 | CXCR2 (0.52) | CXCR2SENP5SENP2SENP1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836158-B1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-02-01 | — | — | EP | disclosed |