Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.47 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4857416 | 0.91 | MAPK14 (0.37) | MAPK14MAPK11MAPK13MAPK12FGFR1 | |
| SCHEMBL4857398 | 0.91 | MAPK14 (0.37) | MAPK14MAPK11MAPK13MAPK12FGFR1 | |
| SCHEMBL4856483 | 0.88 | MAPK14 (0.42) | MAPK14MAPK11MAPK13MAPK12FGFR1 | |
| SCHEMBL4856471 | 0.88 | MAPK14 (0.42) | MAPK14MAPK11MAPK13MAPK12FGFR1 | |
| SCHEMBL4848540 | 0.86 | MAPK14 (0.46) | MAPK14MAPK11MAPK13MAPK12FGFR1 | |
| SCHEMBL4848543 | 0.86 | MAPK14 (0.46) | MAPK14MAPK11MAPK13MAPK12FGFR1 | |
| SCHEMBL4853103 | 0.85 | MAPK14 (0.46) | MAPK14MAPK11MAPK13MAPK12FGFR1 | |
| SCHEMBL4852879 | 0.79 | FGFR1 (0.38) | MAPK14MAPK11MAPK13MAPK12FGFR1 | |
| SCHEMBL4852870 | 0.79 | FGFR1 (0.38) | MAPK14MAPK11MAPK13MAPK12FGFR1 | |
| SCHEMBL4847893 | 0.76 | MAPK14 (0.51) | MAPK14MAPK11MAPK1MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080139588-A1 | Pyrrolo[2,3-d]pyrimidine cytokine inhibitors | THE PROCTER & GAMBLE COMPANY | 2008-06-12 | — | — | US | claimed |
| US-20080139588-A1 | Pyrrolo[2,3-d]pyrimidine cytokine inhibitors | THE PROCTER & GAMBLE COMPANY | 2008-06-12 | — | — | US | disclosed |
| US-7319102-B1 | Pyrrolo[2,3-d]pyrimidine cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2008-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139588-A1 | Pyrrolo[2,3-d]pyrimidine cytokine inhibitors | DPYD, IL1B, IL6 | MAPK14 2806/4885DGAT2 2944/4885MAPK11 3788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.