Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.49 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.49 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | NOS3 | P29474 | 5/20 | 0.47 |
| ▸ | NOS1 | P29475 | 5/20 | 0.47 |
| ▸ | NOS2 | P35228 | 4/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | ACR | P10323 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4861785 | 0.81 | CYP2D6 (0.62) | ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4861629 | 0.78 | NOS3 (0.54) | ALDH1A1SMN1; SMN2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL4854784 | 0.77 | SLC22A2 (0.53) | ALDH1A1NOS3NOS1NOS2PLG | |
| SCHEMBL4858663 | 0.75 | PRSS1 (0.47) | ALDH1A1SMN1; SMN2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5594422 | 0.74 | MAPT (0.46) | ALDH1A1SMN1; SMN2GRIN2BNOS3NOS1 | |
| SCHEMBL23411272 | 0.74 | PLG (0.53) | ALDH1A1SMN1; SMN2GRIN2BNOS3NOS1 | |
| SCHEMBL4857024 | 0.73 | ADRA2A (0.61) | ALDH1A1SMN1; SMN2PRSS1SCN2AKMT2A | |
| SCHEMBL834376 | 0.69 | PLG (0.50) | ALDH1A1SMN1; SMN2PLGMEN1KMT2A | |
| SCHEMBL12900245 | 0.69 | HTT (0.57) | ALDH1A1SMN1; SMN2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1505344 | 0.69 | HTT (0.57) | ALDH1A1SMN1; SMN2GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365069-B2 | Pyrimidone derivatives | BEXEL PHARMACEUTICALS INC. (US) | 2008-04-29 | — | — | US | disclosed |
| US-20040259891-A1 | Novel pyrimidon derivatives | ORCHID CHEMICAL & PHARMACEUTICALS LIMITED (IN) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259891-A1 | Novel pyrimidon derivatives | TYMS, TPMT, TYMP | ALDH1A1 272/4885SMN1; SMN2 2461/4885GRIN2D 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.