Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21213913 | 1.00 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2AMAPT | |
| SCHEMBL3033668 | 0.86 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2AMAPT | |
| SCHEMBL3029057 | 0.86 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2AMAPT | |
| SCHEMBL5845776 | 0.86 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2AMAPT | |
| SCHEMBL6070253 | 0.86 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2AMAPT | |
| SCHEMBL4787850 | 0.84 | MEN1 (0.44) | CHRNB4CHRNA3MEN1KMT2AMAPT | |
| SCHEMBL3034976 | 0.83 | CHRNB4 (0.49) | CHRNB4CHRNA3MEN1KMT2AMAPT | |
| SCHEMBL5582827 | 0.82 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2AMAPT | |
| SCHEMBL5937089 | 0.82 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2AMAPT | |
| SCHEMBL443131 | 0.81 | CA2 (0.67) | CHRNB4CHRNA3MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118935-A1 | COMPOUNDS AND PROCESSES FOR PREPARING SUBSTITUTED AMINOMETHYL-2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-E]INDOL-8-ONES | NEUROGEN CORPORATION (US) | 2008-10-02 | — | — | WO | disclosed |