Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | PNMT | P11086 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3029057 | 0.89 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2APNMT | |
| SCHEMBL3033668 | 0.89 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2APNMT | |
| SCHEMBL6070253 | 0.83 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2AMAPT | |
| SCHEMBL21213913 | 0.83 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2AMAPT | |
| SCHEMBL5845776 | 0.83 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2AMAPT | |
| SCHEMBL4858827 | 0.83 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2AMAPT | |
| SCHEMBL1011267 | 0.83 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2APNMT | |
| SCHEMBL1011265 | 0.83 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2APNMT | |
| SCHEMBL5937089 | 0.80 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2AHTT | |
| SCHEMBL5582827 | 0.80 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466296-B2 | Compounds and processes for preparing substituted aminomethyl-2,3,8,9-tetrahydro-7H-1,4-dioxino[2,3-e]indol-8-ones | LIGAND PHARMACEUTICALS (US) | 2013-06-18 | — | — | US | disclosed |
| US-20100217012-A1 | COMPOUNDS AND PROCESSES FOR PREPARING SUBSTITUTED AMINOMETHYL-2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-e]INDOL-8-ONES | NEUROGEN CORPORATION (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100217012-A1 | COMPOUNDS AND PROCESSES FOR PREPARING SUBSTITUTED AMINOMETHYL-2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-e]INDOL-8-ONES | MTNR1A, HTR3C, MTNR1B | CHRNB4 250/4885CHRNA3 150/4885MEN1 3210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.