SCHEMBL4858908

SCHEMBL4858908

O=C(O)c1c(Oc2ccccc2C(F)(F)F)ccc(C(F)(F)F)c1C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RXRA P19793 1/20 0.47
RXRB P28702 1/20 0.47
RXRG P48443 1/20 0.47
MRGPRX4 Q96LA9 1/20 0.44
RORC P51449 1/20 0.44
PPARG P37231 2/20 0.43
ALDH1A1 P00352 1/20 0.41
HPGD P15428 1/20 0.41
THRA P10827 1/20 0.40
THRB P10828 1/20 0.40
LPAR1 Q92633 1/20 0.40
LPAR5 Q9H1C0 1/20 0.40
STK39 Q9UEW8 1/20 0.40
IDO1 P14902 1/20 0.39
MCL1 Q07820 1/20 0.38
KMO O15229 1/20 0.38
TAS2R14 Q9NYV8 1/20 0.38
RBP4 P02753 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29404903 0.94 RXRA (0.42) RXRARXRBRXRGMRGPRX4RORC
SCHEMBL3193329 0.94 RXRA (0.42) RXRARXRBRXRGMRGPRX4RORC
SCHEMBL15053960 0.88 TTR (0.42) RXRARXRBRXRGLPAR1LPAR5
SCHEMBL29404812 0.87 MRGPRX4 (0.39) RXRARXRBRXRGMRGPRX4ALDH1A1
SCHEMBL3188651 0.87 MRGPRX4 (0.39) RXRARXRBRXRGMRGPRX4ALDH1A1
SCHEMBL7189942 0.86 KDM4E (0.44) RXRARXRBRXRGALDH1A1HPGD
SCHEMBL4854759 0.85 AR (0.45) RXRARXRBRXRGRORCALDH1A1
SCHEMBL3184216 0.83 SCN8A (0.39) RXRARXRBRXRGMRGPRX4LPAR1
SCHEMBL29088055 0.83 MRGPRX4 (0.46) RXRARXRBRXRGMRGPRX4RORC
SCHEMBL3178426 0.81 ALDH1A1 (0.37) RXRARXRBRXRGMRGPRX4RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130161864-A1 SUBSTRATE STRUCTURE AND METHOD FOR MAKING THE SAME CHI MEI CORPORATION (TW) 2013-06-27 US disclosed
US-7450803-B2 Optical waveguide HITACHI CHEMICAL COMPANY, LTD. (JP) 2008-11-11 US disclosed
US-20070086705-A1 Optical waveguide HITACHI CHEMICAL COMPANY, LTD. (JP) 2007-04-19 US disclosed
US-20030054184-A1 Optical element, method for the production thereof and optical module HITACHI CHEMICAL CO., LTD. (JP) 2003-03-20 US disclosed
US-5598501-A Polyimide optical waveguide and method of manufacturing the same NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) 1997-01-28 US disclosed